Before we formulate a product recipe or formulation, we thoroughly examine the current state of research on potential ingredients. This is the only way we can develop products that meet our quality standards.
On this page, we provide an overview of the current data on our ingredients and link to relevant literature. This collection of literature is intended to help you gain an overview of current research findings on the plants we use; however, it does not represent clinical application studies with our products or the extracts we explicitly use. The study results do not allow for any conclusions to be drawn about the efficacy of our products.
Should you have any questions or suggestions, please feel free to contact our customer support at support@fenou.de.
Choose your product
Contents:
balance x cycle
broccoli
Çakır I, Lining Pan P, Hadley CK, El-Gamal A, Fadel A, Elsayegh D, Mohamed O, Rizk NM, Ghamari-Langroudi M. Sulforaphane reduces obesity by reversing leptin resistance. Elife. 2022 Mar 24;11:e67368. doi: 10.7554/eLife.67368. PMID: 35323110; PMCID: PMC8947770.
Chen YJ, Wallig MA, Jeffery EH. Dietary Broccoli Lessens Development of Fatty Liver and Liver Cancer in Mice Given Diethylnitrosamine and Fed a Western or Control Diet. J Nutr. 2016 Mar;146(3):542-50. doi: 10.3945/jn.115.228148. Epub 2016 Feb 10. PMID: 26865652; PMCID: PMC4763488.
Eve AA, Liu X, Wang Y, Miller MJ, Jeffery EH, Madak-Erdogan Z. Biomarkers of Broccoli Consumption: Implications for Glutathione Metabolism and Liver Health. Nutrients. 2020 Aug 20;12(9):2514. doi: 10.3390/nu12092514. PMID: 32825248; PMCID: PMC7551379.
Watercress
https://www.rasayanjournal.co.in/admin/php/upload/341_pdf.pdf
Doustimotlagh AH, Kokhdan EP, Vakilpour H, Khalvati B, Barmak MJ, Sadeghi H, Asfaram A. Protective effect of Nasturtium officinale R. Br and quercetin against cyclophosphamide-induced hepatotoxicity in rats. Mol Biol Rep. 2020 Jul;47(7):5001-5012. doi: 10.1007/s11033-020-05556-7. Epub 2020 Jun 12. PMID: 32533401.
Cruciferous plants
https://www.researchgate.net/profile/Michael-Zeligs/publication/240579847_Diet_and_Estrogen_Status_The_Cruciferous_Connection/links/5c1e832d299bf12be393c368/Diet-and-Estrogen-Status-The-Cruciferous-Connection.pdf
Riby JE, Chang GH, Firestone GL, Bjeldanes LF. Ligand-independent activation of estrogen receptor function by 3, 3'-diindolylmethane in human breast cancer cells. Biochem Pharmacol. 2000 Jul 15;60(2):167-77. doi: 10.1016/s0006-2952(00)00307-5. PMID: 10825461.
Michnovicz JJ, Adlercreutz H, Bradlow HL. Changes in levels of urinary estrogen metabolites after oral indole-3-carbinol treatment in humans. J Natl Cancer Inst. 1997 May 21;89(10):718-23. doi: 10.1093/jnci/89.10.718. PMID: 9168187.
Kandala PK, Wright SE, Srivastava SK. Blocking epidermal growth factor receptor activation by 3,3'-diindolylmethane suppresses ovarian tumor growth in vitro and in vivo. J Pharmacol Exp Ther. 2012 Apr;341(1):24-32. doi: 10.1124/jpet.111.188706. Epub 2011 Dec 28. PMID: 22205686; PMCID: PMC3310701.
Ju YH, Carlson KE, Sun J, Pathak D, Katzenellenbogen BS, Katzenellenbogen JA, Helferich WG.Estrogenic effects of extracts from cabbage, fermented cabbage, and acidified brussels sprouts on growth and gene expression of estrogen-dependent human breast cancer (MCF-7) cells. J Agric Food Chem. 2000 Oct;48(10):4628-34. doi: 10.1021/jf000164z. PMID: 11052710.
Eve AA, Liu X, Wang Y, Miller MJ, Jeffery EH, Madak-Erdogan Z. Biomarkers of Broccoli Consumption: Implications for Glutathione Metabolism and Liver Health. Nutrients. 2020 Aug 20;12(9):2514. doi: 10.3390/nu12092514. PMID: 32825248; PMCID: PMC7551379.
Chen I, McDougal A, Wang F, Safe S. Aryl hydrocarbon receptor-mediated antiestrogenic and antitumorigenic activity of diindolylmethane. Carcinogenesis. 1998 Sep;19(9):1631-9. doi: 10.1093/carcin/19.9.1631. PMID: 9771935.
linseed
Adolphe JL, Whiting SJ, Juurlink BH, Thorpe LU, Alcorn J. Health effects with consumption of the flax lignan secoisolariciresinol diglucoside. Br J Nutr. 2010 Apr;103(7):929-38. doi: 10.1017/S0007114509992753. Epub 2009 Dec 15. PMID: 20003621.
Calado A, Neves PM, Santos T, Ravasco P. The Effect of Flaxseed in Breast Cancer: A Literature Review. Front Nutr. 2018 Feb 7;5:4. doi: 10.3389/fnut.2018.00004. PMID: 29468163; PMCID: PMC5808339.
Chaste tree
Cerqueira RO, Frey BN, Leclerc E, Brietzke E. Vitex agnus castus for premenstrual syndrome and premenstrual dysphoric disorder: a systematic review. Arch Women's Mental Health. 2017 Dec;20(6):713-719. doi: 10.1007/s00737-017-0791-0. Epub 2017 Oct 23. PMID: 29063202.
He Z, Chen R, Zhou Y, Geng L, Zhang Z, Chen S, Yao Y, Lu J, Lin S. Treatment for premenstrual syndrome with Vitex agnus castus: A prospective, randomized, multi-center placebo controlled study in China. Maturitas. 2009 May 20;63(1):99-103. doi: 10.1016/j.maturitas.2009.01.006. Epub 2009 Mar 9. PMID: 19269753.
Ooi SL, Watts S, McClean R, Pak SC. Vitex Agnus-Castus for the Treatment of Cyclic Mastalgia: A Systematic Review and Meta-Analysis. J Womens Health (Larchmt). 2020 Feb;29(2):262-278. doi: 10.1089/jwh.2019.7770. Epub 2019 Aug 29. PMID: 31464546.
rosemary
Greenlee H, Atkinson C, Stanczyk FZ, Lamp JW. A pilot and feasibility study on the effects of naturopathic botanical and dietary interventions on sex steroid hormone metabolism in premenopausal women. Cancer Epidemiol Biomarkers Prev. 2007 Aug;16(8):1601-9. doi: 10.1158/1055-9965.EPI-06-0938. PMID: 17684134.
yam
Jesus M, Martins AP, Gallardo E, Silvestre S. Diosgenin: Recent Highlights on Pharmacology and Analytical Methodology. J Anal Methods Chem. 2016;2016:4156293. doi: 10.1155/2016/4156293. Epub 2016 Dec 28. PMID: 28116217; PMCID: PMC5225340.
Wu WH, Liu LY, Chung CJ, Jou HJ, Wang TA. Estrogenic effect of yam ingestion in healthy postmenopausal women. J Am Coll Nutr. 2005 Aug;24(4):235-43. doi: 10.1080/07315724.2005.10719470. PMID: 16093400.
Wong KL, Lai YM, Li KW, Lee KF, Ng TB, Cheung HP, Zhang YB, Lao L, Wong RN, Shaw PC, Wong JH, Zhang ZJ, Lam JK, Ye WC, Sze SC. A Novel, Stable, Estradiol-Stimulating, Osteogenic Yam Protein with Potential for the Treatment of Menopausal Syndrome. Sci Rep. 2015 Jul 10;5:10179. doi: 10.1038/srep10179. Erratum in: Sci Rep. 2015 Dec 18;5:17129. doi: 10.1038/srep17129.. Wencai, YE [corrected to Ye, Wen-cai]. PMID: 26160710; PMCID: PMC5155516.
Zhang X, Jin M, Tadesse N, Dang J, Zhou T, Zhang H, Wang S, Guo Z, Ito Y. Dioscorea zingiberensis CHWright: An overview on its traditional use, phytochemistry, pharmacology, clinical applications, quality control, and toxicity. J Ethnopharmacol. 2018 Jun 28;220:283-293. doi: 10.1016/j.jep.2018.03.017. Epub 2018 Mar 28. PMID: 29602601.
beauty x cycle
Stinging nettle
Moini Jazani A, Hamdi K, Tansaz M, Nazemiyeh H, Sadeghi Bazargani H, Fazljou SMB, Nasimi Doost Azgomi R. Herbal Medicine for Oligomenorrhea and Amenorrhea: A Systematic Review of Ancient and Conventional Medicine. Biomed Res Int. 2018 Mar 18;2018:3052768. doi: 10.1155/2018/3052768. PMID: 29744355; PMCID: PMC5878906.
Schöttner M, Gansser D, Spiteller G. Lignans from the roots of Urtica dioica and their metabolites bind to human sex hormone binding globulin (SHBG). Planta Med. 1997 Dec;63(6):529-32. doi: 10.1055/s-2006-957756. PMID: 9434605.
Dhouibi R, Affes H, Ben Salem M, Hammami S, Sahnoun Z, Zeghal KM, Ksouda K. Screening of pharmacological uses of Urtica dioica and other benefits. Prog Biophys Mol Biol. 2020 Jan;150:67-77. doi: 10.1016/j.pbiomolbio.2019.05.008. Epub 2019 Jun 1. PMID: 31163183.
Pekmezci E, Türkoğlu M. URTICA DIOICA EXTRACT DOWNREGULATES THE GENE EXPRESSION OF 5Α-RII IN HACAT CELLS: POSSIBLE IMPLICATIONS AGAINST ANDROGENIC SKIN DISEASES. Georgian Med News. 2023 Jan;(334):6-9. PMID: 36864786.
rosemary
Zhu BT, Loder DP, Cai MX, Ho CT, Huang MT, Conney AH. Dietary administration of an extract from rosemary leaves enhances the liver microsomal metabolism of endogenous estrogens and decreases their uterotropic action in CD-1 mice. Carcinogenesis. 1998 Oct;19(10):1821-7. doi: 10.1093/carcin/19.10.1821. PMID: 9806165.
al-Sereiti MR, Abu-Amer KM, Sen P. Pharmacology of rosemary (Rosmarinus officinalis Linn.) and its therapeutic potentials. Indian J Exp Biol. 1999 Feb;37(2):124-30. PMID: 10641130.
Greenlee H, Atkinson C, Stanczyk FZ, Lamp JW. A pilot and feasibility study on the effects of naturopathic botanical and dietary interventions on sex steroid hormone metabolism in premenopausal women. Cancer Epidemiol Biomarkers Prev. 2007 Aug;16(8):1601-9. doi: 10.1158/1055-9965.EPI-06-0938. PMID: 17684134.
Panahi Y, Taghizadeh M, Marzony ET, Sahebkar A. Rosemary oil vs minoxidil 2% for the treatment of androgenetic alopecia: a randomized comparative trial. Skinmed. 2015 Jan-Feb;13(1):15-21. PMID: 25842469.
Murata K, Noguchi K, Kondo M, Onishi M, Watanabe N, Okamura K, Matsuda H. Promotion of hair growth by Rosmarinus officinalis leaf extract. Phytother Res. 2013 Feb;27(2):212-7. doi: 10.1002/ptr.4712. Epub 2012 Apr 20. PMID: 22517595.
Dhariwala MY, Ravikumar P. An overview of herbal alternatives in androgenetic alopecia. J Cosmet Dermatol. 2019 Aug;18(4):966-975. doi: 10.1111/jocd.12930. Epub 2019 Apr 13. PMID: 30980598.
Saw palmetto
Murugusundram S. Serenoa Repens: Does It have Any Role in the Management of Androgenetic Alopecia? J Cutan Aesthet Surg. 2009 Jan;2(1):31-2. doi: 10.4103/0974-2077.53097. PMID: 20300369; PMCID: PMC2840915.
Prager N, Bickett K, French N, Marcovici G. A randomized, double-blind, placebo-controlled trial to determine the effectiveness of botanically derived inhibitors of 5-alpha-reductase in the treatment of androgenetic alopecia. J Altern Complement Med. 2002 Apr;8(2):143-52. doi: 10.1089/acm.2002.8.143. Erratum in: J Altern Complement Med. 2006 Mar;12(2):199. PMID: 12006122.
Rossi A, Mari E, Scarno M, Garelli V, Maxia C, Scali E, Iorio A, Carlesimo M. Comparative effectiveness of finasteride vs Serenoa repens in male androgenetic alopecia: a two-year study. Int J Immunopathol Pharmacol. 2012 Oct-Dec;25(4):1167-73. doi: 10.1177/039463201202500435. PMID: 23298508.
mood x cycle
Ashwagandha
Speers AB, Cabey KA, Soumyanath A, Wright KM. Effects of Withania somnifera (Ashwagandha) on Stress and the Stress-Related Neuropsychiatric Disorders Anxiety, Depression, and Insomnia. Curr Neuropharmacol. 2021;19(9):1468-1495. doi: 10.2174/1570159X19666210712151556. PMID: 34254920; PMCID: PMC8762185.
Griffonia simplicifolia
Muszyńska B, Łojewski M, Rojowski J, Opoka W, Sułkowska-Ziaja K. Natural products of relevance in the prevention and supportive treatment of depression. Psychiatrist Pol. 2015 May-Jun;49(3):435-53. English, Polish. doi: 10.12740/PP/29367. PMID: 26276913.
Wu L, Ran L, Wu Y, Liang M, Zeng J, Ke F, Wang F, Yang J, Lao X, Liu L, Wang Q, Gao X. Oral administration of 5-hydroxytryptophan restores gut microbiota dysbiosis in a mouse model of depression. Front Microbiol. 2022 Apr 28;13:864571. doi: 10.3389/fmicb.2022.864571. PMID: 35572711; PMCID: PMC9096562.
Green tea
Williams JL, Everett JM, D'Cunha NM, Sergi D, Georgousopoulou EN, Keegan RJ, McKune AJ, Mellor DD, Anstice N, Naumovski N. The Effects of Green Tea Amino Acid L-Theanine Consumption on the Ability to Manage Stress and Anxiety Levels: a Systematic Review. Plant Foods Hum Nutr. 2020 Mar;75(1):12-23. doi: 10.1007/s11130-019-00771-5. PMID: 31758301.
magnesium
Saba S, Faizi F, Sepandi M, Nehrir B. Effect of short-term magnesium supplementation on anxiety, depression and sleep quality in patients after open-heart surgery. Magnes Res. 2022 Apr 1;35(2):62-70. English. doi: 10.1684/mrh.2022.0503. PMID: 36354243.
Noah L, Dye L, Bois De Fer B, Mazur A, Pickering G, Pouteau E. Effect of magnesium and vitamin B6 supplementation on mental health and quality of life in stressed healthy adults: Post-hoc analysis of a randomized controlled trial. Stress Health. 2021 Dec;37(5):1000-1009. doi: 10.1002/smi.3051. Epub 2021 May 6. PMID: 33864354; PMCID: PMC9292249.
Saffron
Muszyńska B, Łojewski M, Rojowski J, Opoka W, Sułkowska-Ziaja K. Natural products of relevance in the prevention and supportive treatment of depression. Psychiatrist Pol. 2015 May-Jun;49(3):435-53. English, Polish. doi: 10.12740/PP/29367. PMID: 26276913.
Shamabadi A, Hasanzadeh A, Akhondzadeh S. The neuropsychotropic effects of Crocus sativus L. (saffron): an overview of systematic reviews and meta-analyses investigating its clinical efficacy in psychiatric and neurological disorders. Avicenna J Phytomed. 2022 Sep-Oct;12(5):475-488. doi: 10.22038/AJP.2021.19300. PMID: 36249453; PMCID: PMC9516399.
Siddiqui SA, Ali Redha A, Snoeck ER, Singh S, Simal-Gandara J, Ibrahim SA, Jafari SM. Anti-Depressant Properties of Crocin Molecules in Saffron. Molecules. 2022 Mar 23;27(7):2076. doi: 10.3390/molecules27072076. PMID: 35408474; PMCID: PMC9000812.
Taurine
Wu G, Zhou J, Yang M, Xu C, Pang H, Qin X, Lin S, Yang J, Hu J. The regulatory effects of taurine on neurogenesis and apoptosis of neural stem cells in the hippocampus of rats. Adv Exp Med Biol 2022;1370:351-367. doi: 10.1007/978-3-030-93337-1_34. PMID: 35882810.
zinc
Gower-Winter SD, Levenson CW. Zinc in the central nervous system: From molecules to behavior. Biofactors. 2012 May-Jun;38(3):186-93. doi: 10.1002/biof.1012. Epub 2012 Mar 31. PMID: 22473811; PMCID: PMC3757551.
reset x cycle
Chlorella
Bito T, Okumura E, Fujishima M, Watanabe F. Potential of Chlorella as a Dietary Supplement to Promote Human Health. Nutrients. 2020 Aug 20;12(9):2524. doi: 10.3390/nu12092524. PMID: 32825362; PMCID: PMC7551956.
Milk thistle
Aghemo A, Alekseeva OP, Angelico F, Bakulin IG, Bakulina NV, Bordin D, Bueverov AO, Drapkina OM, Gillessen A, Kagarmanova EM, Korochanskaya NV, Kucheryavii UA, Lazebnik LB, Livzan MA, Maev IV, Martynov AI, Osipenko MF, Sas EI, Starodubova A, Uspensky YP, Vinnitskaya EV, Yakovenko EP, Yakovlev AA. Role of silymarin as antioxidant in clinical management of chronic liver diseases: a narrative review. Ann Med. 2022 Dec;54(1):1548-1560. doi: 10.1080/07853890.2022.2069854. PMID: 35635048; PMCID: PMC9186366.
rosemary
Greenlee H, Atkinson C, Stanczyk FZ, Lamp JW. A pilot and feasibility study on the effects of naturopathic botanical and dietary interventions on sex steroid hormone metabolism in premenopausal women. Cancer Epidemiol Biomarkers Prev. 2007 Aug;16(8):1601-9. doi: 10.1158/1055-9965.EPI-06-0938. PMID: 17684134.
Zhu BT, Loder DP, Cai MX, Ho CT, Huang MT, Conney AH. Dietary administration of an extract from rosemary leaves enhances the liver microsomal metabolism of endogenous estrogens and decreases their uterotropic action in CD-1 mice. Carcinogenesis. 1998 Oct;19(10):1821-7. doi: 10.1093/carcin/19.10.1821. PMID: 9806165.
Ramadan KS, Khalil OA, Danial EN, Alnahdi HS, Ayaz NO. Hypoglycemic and hepatoprotective activity of Rosmarinus officinalis extract in diabetic rats. J Physiol Biochem. 2013 Dec;69(4):779-83. doi: 10.1007/s13105-013-0253-8. Epub 2013 Apr 28. PMID: 23625639.
Red clover
Beck V, Rohr U, Jungbauer A. Phytoestrogens derived from red clover: an alternative to estrogen replacement therapy? J Steroid Biochem Mol Biol. 2005 Apr;94(5):499-518. doi: 10.1016/j.jsbmb.2004.12.038. Epub 2005 Mar 23. PMID: 15876415.
Masuda T, Ino Y, Hirai A, Okamura A, Ishikawa H, Yokoyama SI, Osawa T. Effects of isoflavone-rich red clover extract on blood glucose level: A randomized, double-blind, placebo-controlled trial. J Food Sci. 2021 Apr;86(4):1393-1399. doi: 10.1111/1750-3841.15672. Epub 2021 Mar 24. PMID: 33761143.
Flora Pro X Health
Microorganisms Species
Liu Z, de Bruijn WJC, Bruins ME, Vincken JP. Reciprocal Interactions between Epigallocatechin-3-gallate (EGCG) and Human Gut Microbiota In vitro. J Agric Food Chem. 2020 Sep 9;68(36):9804-9815. doi: 10.1021/acs.jafc.0c03587. Epub 2020 Aug 26. PMID: 32808768; PMCID: PMC7496747.
Mlcek J, Jurikova T, Skrovankova S, Sochor J. Quercetin and Its Anti-Allergic Immune Response. Molecules. 2016 May 12;21(5):623. doi: 10.3390/molecules21050623. PMID: 27187333; PMCID: PMC6273625.
flora daily x health
Dietary fiber in general
Gill SK, Rossi M, Bajka B, Whelan K. Dietary fiber in gastrointestinal health and disease. Nat Rev Gastroenterol Hepatol. 2021 Feb;18(2):101-116. doi: 10.1038/s41575-020-00375-4. Epub 2020 Nov 18. PMID: 33208922.
Konjac root
Devaraj RD, Reddy CK, Xu B. Health-promoting effects of konjac glucomannan and its practical applications: A critical review. Int J Biol Macromol. 2019 Apr 1;126:273-281. doi: 10.1016/j.ijbiomac.2018.12.203. Epub 2018 Dec 23. PMID: 30586587.
L-Arginine
Bekebrede AF, Keijer J, Gerrits WJJ, Boer VCJ. The Molecular and Physiological Effects of Protein-Derived Polyamines in the Intestine. Nutrients. 2020 Jan 11;12(1):197. doi: 10.3390/nu12010197. PMID: 31940783; PMCID: PMC7020012.
Bekebrede AF, Keijer J, Gerrits WJJ, Boer VCJ. The Molecular and Physiological Effects of Protein-Derived Polyamines in the Intestine. Nutrients. 2020 Jan 11;12(1):197. doi: 10.3390/nu12010197. PMID: 31940783; PMCID: PMC7020012.
rise x menopause
Essential oils (lemongrass)
https://www.primaveralife.com/aromatherapie/pflanzenglossar/lemongrass
Densorphin
Glycerin
https://www.haut.de/inhaltsstoffe-inci/inci-detail/5951/glycerin/
Adolphe JL, Whiting SJ, Juurlink BH, Thorpe LU, Alcorn J. Health effects with consumption of the flax lignan secoisolariciresinol diglucoside. Br J Nutr. 2010 Apr;103(7):929-38. doi: 10.1017/S0007114509992753. Epub 2009 Dec 15. PMID: 20003621.
Calado A, Neves PM, Santos T, Ravasco P. The Effect of Flaxseed in Breast Cancer: A Literature Review. Front Nutr. 2018 Feb 7;5:4. doi: 10.3389/fnut.2018.00004. PMID: 29468163; PMCID: PMC5808339.
Macadamia nut oil
https://www.haut.de/inhaltsstoffe-inci/inci-detail/8478/macadamia-integrifolia-seed-oil/
almond oil
https://www.haut.de/inhaltsstoffe-inci/inci-detail/13265/prunus-amygdalus-dulcis-oil/
Ho R, Teai T, Meybeck A, Raharivelomanana P. UV-protective effects of phytoecdysteroids from Microsorum grossum extracts on human dermal fibroblasts. Nat Prod Commun. 2015 Jan;10(1):33-6. PMID: 25920214.
Shea butter
https://www.haut.de/inhaltsstoffe-inci/inci-detail/18767/butyrospermum-parkii-butter/
Soy isoflavones
Rzepecki AK, Murase JE, Juran R, Fabi SG, McLellan BN. Estrogen-deficient skin: The role of topical therapy. Int J Womens Dermatol. 2019 Mar 15;5(2):85-90. doi: 10.1016/j.ijwd.2019.01.001. PMID: 30997378; PMCID: PMC6451761.
shine x menopause
Ashwagandha
Mandlik Ingawale DS, Namdeo AG. Pharmacological evaluation of Ashwagandha highlighting its healthcare claims, safety, and toxicity aspects. J Diet Suppl. 2021;18(2):183-226. doi: 10.1080/19390211.2020.1741484. Epub 2020 Apr 3. PMID: 32242751.
Essential oils (lavender)
https://www.primaveralife.com/aromatherapie/pflanzenglossar/lavendel
Uzunçakmak T, Ayaz Alkaya S. Effect of aromatherapy on coping with premenstrual syndrome: A randomized controlled trial. Complement Ther Med. 2018 Feb;36:63-67. doi: 10.1016/j.ctim.2017.11.022. Epub 2017 Dec 1. PMID: 29458934.
Cavanagh HM, Wilkinson JM. Biological activities of lavender essential oil. Phytother Res. 2002 Jun;16(4):301-8. doi: 10.1002/ptr.1103. PMID: 12112282.
CBD
Peng J, Fan M, An C, Ni F, Huang W, Luo J.A narrative review of molecular mechanism and therapeutic effect of cannabidiol (CBD). Basic Clin Pharmacol Toxicol. 2022 Apr;130(4):439-456. doi: 10.1111/bcpt.13710. Epub 2022 Feb 6. PMID: 35083862.
Macadamia nut oil
https://www.haut.de/inhaltsstoffe-inci/inci-detail/8478/macadamia-integrifolia-seed-oil/
almond oil
https://www.haut.de/inhaltsstoffe-inci/inci-detail/13265/prunus-amygdalus-dulcis-oil/
Shea butter
https://www.haut.de/inhaltsstoffe-inci/inci-detail/18767/butyrospermum-parkii-butter/
yam
Jesus M, Martins AP, Gallardo E, Silvestre S. Diosgenin: Recent Highlights on Pharmacology and Analytical Methodology. J Anal Methods Chem. 2016;2016:4156293. doi: 10.1155/2016/4156293. Epub 2016 Dec 28. PMID: 28116217; PMCID: PMC5225340.
clear skin x cycle
Aloe vera
Sánchez M, González-Burgos E, Iglesias I, Gómez-Serranillos MP. Pharmacological Update Properties of Aloe Vera and its Major Active Constituents. Molecules. 2020 Mar 13;25(6):1324. doi: 10.3390/molecules25061324. PMID: 32183224; PMCID: PMC7144722.
Fox LT, Gerber M, du Preez JL, du Plessis J, Hamman JH. Skin permeation enhancement effects of the gel and whole-leaf materials of Aloe vera, Aloe marlothii and Aloe ferox. J Pharm Pharmacol. 2015 Jan;67(1):96-106. doi: 10.1111/jphp.12311. Epub 2014 Sep 5. PMID: 25196486.
Capryloyl salicylic acid
Oresajo C, Yatskayer M, Hansenne I. Clinical tolerance and efficacy of capryloyl salicylic acid peel compared to a glycolic acid peel in subjects with fine lines/wrinkles and hyperpigmented skin. J Cosmet Dermatol. 2008 Dec;7(4):259-62. doi: 10.1111/j.1473-2165.2008.00403.x. PMID: 19146601.
Curcumin derivative
Zia A, Farkhondeh T, Pourbagher-Shahri AM, Samarghandian S. The role of curcumin in aging and senescence: Molecular mechanisms. Biomed Pharmacother. 2021 Feb;134:111119. doi: 10.1016/j.biopha.2020.111119. Epub 2020 Dec 24. PMID: 33360051.
Glycerin
Fluhr JW, Darlenski R, Surber C. Glycerol and the skin: holistic approach to its origin and functions. Br J Dermatol. 2008 Jul;159(1):23-34. doi: 10.1111/j.1365-2133.2008.08643.x. Epub 2008 Jul 1. PMID: 18510666.
Verdier-Sévrain S, Bonté F. Skin hydration: a review on its molecular mechanisms. J Cosmet Dermatol. 2007 Jun;6(2):75-82. doi: 10.1111/j.1473-2165.2007.00300.x. PMID: 17524122.
Glycyrrhetinic acid
Pastorino G, Cornara L, Soares S, Rodrigues F, Oliveira MBPP. Liquorice (Glycyrrhiza glabra): A phytochemical and pharmacological review. Phytother Res. 2018 Dec;32(12):2323-2339. doi: 10.1002/ptr.6178. Epub 2018 Aug 17. PMID: 30117204; PMCID: PMC7167772.
Hyaluronic acid
Verdier-Sévrain S, Bonté F. Skin hydration: a review on its molecular mechanisms. J Cosmet Dermatol. 2007 Jun;6(2):75-82. doi: 10.1111/j.1473-2165.2007.00300.x. PMID: 17524122.
Isostearyl isostearate
Dederen JC, Chavan B, Rawlings AV. Emollients are more than sensory ingredients: the case of isostearyl isostearate. Int J Cosmet Sci. 2012 Dec;34(6):502-10. doi: 10.1111/j.1468-2494.2012.00744.x. PMID: 22913650.
Niacinamide
https://www.researchgate.net/profile/Paul-Matts/publication/286270242_A_Review_of_the_range_of_effects_of_niacinamide_in_human_skin/links/57601eef08ae2b8d20eb27ba/A-Review-of-the-range-of-effects-of-niacinamide-in-human-skin.pdf?ref=myskintips.com
Madaan P, Sikka P, Malik DS. Cosmeceutical Aptitudes of Niacinamide: A Review. Recent Adv Antiinfect Drug Discov. 2021;16(3):196-208. doi: 10.2174/2772434416666211129105629. PMID: 34844552.
OLT®
Antonescu Mintas AI, Miere Groza F, Fritea L, Ganea M, Zdrinca M, Dobjanschi L, Antonescu A, Vicas SI, Bodog F, Sindhu RK, Cavalu S. Perspectives on the combined effects of Ocimum basilicum and Trifolium pratense Extracts in Terms of Phytochemical Profile and Pharmacological Effects. Plants (Basel). 2021 Jul 7;10(7):1390. doi: 10.3390/plants10071390. PMID: 34371593; PMCID: PMC8309466.
Mohsen A, Fatemeh K, Leila N, Mona P, Mohammad Z, Mozafar K. Pharmacological and therapeutic properties of the Red Clover (Trifolium pratense L.): an overview of the new finding. J Tradit Chin Med. 2021 Aug;41(4):642-649. doi: 10.19852/j.cnki.jtcm.20210324,001. PMID: 34392659.
Lee KS, Cha HJ, Lee GT, Lee KK, Hong JT, Ahn KJ, An IS, An S, Bae S. Troxerutin induces protective effects against ultraviolet B radiation through the alteration of microRNA expression in human HaCaT keratinocyte cells. Int J Mol Med. 2014 Apr;33(4):934-42. doi: 10.3892/ijmm.2014.1641. Epub 2014 Feb 3. PMID: 24503859.
zinc
Stamatiadis D, Bulteau-Portois MC, Mowszowicz I. Inhibition of 5 alpha-reductase activity in human skin by zinc and azelaic acid. Br J Dermatol. 1988 Nov;119(5):627-32. doi: 10.1111/j.1365-2133.1988.tb03474.xPMID: 3207614.
grow x cycle
Aloe vera
Fox LT, Gerber M, du Preez JL, du Plessis J, Hamman JH. Skin permeation enhancement effects of the gel and whole-leaf materials of Aloe vera, Aloe marlothii and Aloe ferox. J Pharm Pharmacol. 2015 Jan;67(1):96-106. doi: 10.1111/jphp.12311. Epub 2014 Sep 5. PMID: 25196486.
Lourith N, Kanlayavattanakul M. Hair loss and herbs for treatment. J Cosmet Dermatol. 2013 Sep;12(3):210-22. doi: 10.1111/jocd.12051. PMID: 23992163.
Stinging nettle
Pekmezci E, Türkoğlu M. URTICA DIOICA EXTRACT DOWNREGULATES THE GENE EXPRESSION OF 5Α-RII IN HACAT CELLS: POSSIBLE IMPLICATIONS AGAINST ANDROGENIC SKIN DISEASES. Georgian Med News. 2023 Jan;(334):6-9. PMID: 36864786.
Active ingredient complexes
Loing E, Lachance R, Ollier V, Hocquaux M. A new strategy to modulate alopecia using a combination of two specific and unique ingredients. J Cosmetic Sci. 2013 Jan-Feb;64(1):45-58. PMID: 23449130.
Evans BA, Griffiths K, Morton MS. Inhibition of 5 alpha-reductase in genital skin fibroblasts and prostate tissue by dietary lignans and isoflavonoids. J Endocrinol. 1995 Nov;147(2):295-302. doi: 10.1677/joe.0.1470295. PMID: 7490559.
Olsen EA, Hordinsky M, Whiting D, Stough D, Hobbs S, Ellis ML, Wilson T, Rittmaster RS; Dutasteride Alopecia Research Team. The importance of dual 5alpha-reductase inhibition in the treatment of male pattern hair loss: results of a randomized placebo-controlled study of dutasteride versus finasteride.J Am Acad Dermatol. 2006 Dec;55(6):1014-23. doi: 10.1016/j.jaad.2006.05.007. PMID: 17110217.
Sharquie KE, Al-Obaidi HK. Onion juice (Allium cepa L.), a new topical treatment for alopecia areata. J Dermatol. 2002 Jun;29(6):343-6. doi: 10.1111/j.1346-8138.2002.tb00277.xPMID: 12126069.
Matsuda H, Yamazaki M, Asanuma Y, Kubo M. Promotion of hair growth by ginseng radix on cultured mouse vibrissal hair follicles. Phytother Res. 2003 Aug;17(7):797-800. doi: 10.1002/ptr.1241. PMID: 12916080.
Stamatiadis D, Bulteau-Portois MC, Mowszowicz I. Inhibition of 5 alpha-reductase activity in human skin by zinc and azelaic acid. Br J Dermatol. 1988 Nov;119(5):627-32. doi: 10.1111/j.1365-2133.1988.tb03474.xPMID: 3207614.
D-Panthenol
Shin JY, Kim J, Choi YH, Kang NG, Lee S. Dexpanthenol Promotes Cell Growth by Preventing Cell Senescence and Apoptosis in Cultured Human Hair Follicle Cells. Curr Issues Mol Biol. 2021 Sep 28;43(3):1361-1373. doi: 10.3390/cimb43030097. PMID: 34698060; PMCID: PMC8929036.
Green tea
Nualsri C, Lourith N, Kanlayavattanakul M. Development and clinical evaluation of green tea hair tonic for greasy scalp treatment. J Cosmetic Sci. 2016 May-Jun;67(3):161-66. PMID: 29394016.
Lourith N, Kanlayavattanakul M. Hair loss and herbs for treatment. J Cosmet Dermatol. 2013 Sep;12(3):210-22. doi: 10.1111/jocd.12051. PMID: 23992163.
Davis SL, Marsh JM, Kelly CP, Li L, Tansky CS, Fang R, Simmonds MSJ. Protection of hair from damage induced by ultraviolet irradiation using tea (Camellia sinensis) extracts. J Cosmet Dermatol. 2022 May;21(5):2246-2254. doi: 10.1111/jocd.14387. Epub 2021 Aug 20. PMID: 34416057.
chamomile
Miraj S, Alesaeidi S. A systematic review study of therapeutic effects of Matricaria recuitta chamomile (chamomile). Electron Physician. 2016 Sep 20;8(9):3024-3031. doi: 10.19082/3024. PMID: 27790360; PMCID: PMC5074766.
Huh S, Lee J, Jung E, Kim SC, Kang JI, Lee J, Kim YW, Sung YK, Kang HK, Park D. A cell-based system for screening hair growth-promoting agents. Arch Dermatol Res. 2009 Jun;301(5):381-5. doi: 10.1007/s00403-009-0931-0. Epub 2009 Mar 11. PMID: 19277688.
Kerazyme Protect
Panahi Y, Taghizadeh M, Marzony ET, Sahebkar A. Rosemary oil vs minoxidil 2% for the treatment of androgenetic alopecia: a randomized comparative trial. Skinmed. 2015 Jan-Feb;13(1):15-21. PMID: 25842469.
Murata K, Noguchi K, Kondo M, Onishi M, Watanabe N, Okamura K, Matsuda H. Promotion of hair growth by Rosmarinus officinalis leaf extract. Phytother Res. 2013 Feb;27(2):212-7. doi: 10.1002/ptr.4712. Epub 2012 Apr 20. PMID: 22517595.
Murugusundram S. Serenoa Repens: Does It have Any Role in the Management of Androgenetic Alopecia? J Cutan Aesthet Surg. 2009 Jan;2(1):31-2. doi: 10.4103/0974-2077.53097. PMID: 20300369; PMCID: PMC2840915.
Prager N, Bickett K, French N, Marcovici G. A randomized, double-blind, placebo-controlled trial to determine the effectiveness of botanically derived inhibitors of 5-alpha-reductase in the treatment of androgenetic alopecia. J Altern Complement Med. 2002 Apr;8(2):143-52. doi: 10.1089/acm.2002.8.143.Erratum in: J Altern Complement Med. 2006 Mar;12(2):199. PMID: 12006122.
Rossi A, Mari E, Scarno M, Garelli V, Maxia C, Scali E, Iorio A, Carlesimo M. Comparative effectiveness of finasteride vs Serenoa repens in male androgenetic alopecia: a two-year study. Int J Immunopathol Pharmacol. 2012 Oct-Dec;25(4):1167-73. doi: 10.1177/039463201202500435. PMID: 23298508.
Horsetail
Chaiyana W, Punyoyai C, Somwongin S, Leelapornpisid P, Ingkaninan K, Waranuch N, Srivilai J, Thitipramote N, Wisuitiprot W, Schuster R, Viernstein H, Mueller M. Inhibition of 5α-Reductase, IL-6 Secretion, and Oxidation Process of Equisetum debile Roxb. ex Vaucher Extract as Functional Food and Nutraceuticals Ingredients. Nutrients. 2017 Oct 10;9(10):1105. doi: 10.3390/nu9101105. PMID: 28994714; PMCID: PMC5691721.